The Royal Tobacco Factory is located right next to the University of Seville. There are various public transport options to take you there. You may use the metro line L1 and exit and the metro stop called Puerta Jarez. You may also use the tram line T1 and exit at the stop called Puerta de Jarez. You may also use the following bus lines: 5, 21, C3 or A2. The bus stop where you should exit is called: Palos de La Frontera (Puerta Jerez).